St. Hippolytus: If someone makes an offering of oil, the bishop shall give thanks in the same manner as for the oblation of the bread and wine. He does not give thanks with the same words, but quite similar, saying, “Sanctify this oil, God, as you give holiness to all who are anointed and receive it, as you anointed kings, priests, and prophets, so that it may give strength to all who taste it, and health to all who use it” (The Apostolic Tradition 5:1-2 [A.D. 215]).
Origen: [The penitent Christian] does not shrink from declaring his sin to a priest of the Lord and from seeking medicine . . . [of] which the apostle James says: ‘If then there is anyone sick, let him call the presbyters of the Church, and let them impose hands upon him, anointing him with oil in the name of the Lord; and the prayer of faith will save the sick man, and if he be in sins, they shall be forgiven him. (Homilies on Leviticus 2:4 [A.D. 250]).
Council of Nicaea: Concerning the departing, the ancient canonical law is still to be maintained, to wit, that, if any man be at the point of death, he must not be deprived of the last and most indispensable Viaticum (Canon 13 [A.D. 325]).
St. Aphraates: [O]f the sacrament of life, by which Christians [baptism], priests [in ordination], kings and prophets are made perfect; it illuminates darkness [in confirmation], anoints the sick, and by its secret sacrament restores penitents (Treatises 23:3 [A.D. 345]).
St. Serapion: We beseech you, Savior of all men, you that have all virtue and power, Father of our Lord and Savior Jesus Christ, and we pray that you send down from heaven the healing power of the only-begotten [Son] upon this oil, so that for those who are anointed . . . it may be effected for the casting out of every disease and every bodily infirmity . . . for good grace and remission of sins . . . (The Sacramentary of Serapion 29:1 [A.D. 350]).
St. Ephraem: They pray over thee; one blows on thee; another seals thee (Homily 46 [ante A.D. 373]).
St. John Chrysostom: The priests of Judaism had power to cleanse the body from leprosy—or rather, not to cleanse it at all, but to declare a person as having been cleansed. . .. Our priests have received the power not of treating with the leprosy of the body, but with spiritual uncleanness; not of declaring cleansed, but of actually cleansing. . .. Priests accomplish this not only by teaching and admonishing, but also by the help of prayer. Not only at the time of our regeneration [in baptism], but even afterward, they have the authority to forgive sins: “Is there anyone among you sick? Let him call in the priests of the church, and let them pray over him, anointing him with oil in the name of the Lord. And the prayer of faith shall save the sick man, and the Lord shall raise him up, and if he has committed sins, he shall be forgiven” (On the Priesthood 3:6:190ff [A.D. 387]).
St. Ambrose: Why, then, do you lay on hands, and believe it to be the effect of the blessing, if perchance some sick person recovers? Why do you assume that any can be cleansed by you from the pollution of the devil? Why do you baptize if sins cannot be remitted by man? If baptism is certainly the remission of all sins, what difference does it make whether priests claim that this power is given to them in penance or at the font? In each the mystery is one (Penance 1:8:36 [A.D. 390]).
St. Jerome: There came also Constantia a holy woman whose son-in-law and daughter he had anointed with oil and saved from death (Life of Saint Hilarion 44 [A.D. 392]).
St. Cyril of Alexandria: [I]f some part of your body is suffering…recall also the saying in the divinely inspired Scripture: “Is anyone among you ill? Let him call the presbyters of the Church and let them pray over him, anointing him with oil in the name of the Lord. And the prayer of faith will save the sick man, and the Lord will raise him up, and if he be in sins they shall be forgiven” (James 5:14-15) (Worship and Adoration, 6 [A.D. 412]).
Pope Innocent: [I]n the epistle of the blessed Apostle James…’If anyone among you is sick, let him call the priests… There is no doubt that this anointing ought to be interpreted or understood of the sick faithful, who can be anointed with the holy oil of chrism…it is a kind of sacrament (To Decentius, 25:8:11 [A.D. 416]).
St. Hilary of Arles: Whenever some illness comes upon man, he should hurry back to the Church. Let him receive the body and blood of Christ, be anointed by the presbyters with consecrated oil and ask them and the deacons to pray over him in Christ’s name. If he does this, he will receive not only bodily health but also forgiveness of his sins (Sermon 19:5 [circa A.D. 440]).